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How Silver as Anti-fungal Agent

How Silver as Anti-fungal Agent

Lee et. al. 2010

“This result show that silver at 3 PPM could be applied as therapeutic agents regarding human fungal diseases with low
cytotoxicity as the result indicates that silver affected fungus cells by attacking their membranes, thus disrupting membrane
potential and inhibited some fungal RNA processes which are involved in fungal bud growth. The fact that silver is cost-effective
is also of importance as it can be expected that silver has potential as an anti-infective agent for human fungal diseases.”

Ionic Silver 3 PPM as Anti-microbial

Ionic Silver 3 PPM as Anti-microbial

Lkhagvajva et. al. 2011

“The results have demonstrated that water bound silver dispersions show a pronounced antibacterial effect,
as evidenced by a very low concentration of 2–4 PPM of silver particles against all tested microorganisms.
This very high activity could be related to the advantages induced through the water bound method since very
small silver particles were obtained which makes them very active against microorganisms. SEM investigations
of the morphology changes of those bacteria showed that the surfaces of the cell walls of both bacteria were
disrupted by Ag nanoparticles.”

How Silver Destroy E. coli Metabolism

How Silver Destroy E. coli Metabolism

Mikihiro et. al. 2005

“The study shows that the expression of a ribosomal subunit protein, as well as that of some other enzymes
and proteins of the anaerobic prokaryote cell necessary for the metabolism of the microbe, is affected by
the silver ion and the harmful development of the organism is disrupted and the anaerobic prokaryote cell
is suffocated and discharged by the immune system.”

Silver on Biofilm on S. epidermidis

Silver on Biofilm on S. epidermidis

Kalimuthu et.al.2010

“Staphylococci epidermis biofilms have been found to be markedly impaired by very low, non-inhibitory levels of silver ions.
This is important news, since biofilms give communities of microorganisms a distinct ability to resist antibiotic drugs.
If low levels of silver ions can impair biofilms, then its use may well help resolve one factor in the growing problem of
antibiotic-resistant microorganisms. The studies on the intermolecular forces within the EPSs of S. epidermidis and
S. epidermidis biofilms suggest that the silver ions can destabilize the biofilm matrix by binding to electron donor groups
of the biological molecules. This leads to reductions in the number of binding sites for hydrogen bonds and electrostatic and
hydrophobic interactions and, hence, the destabilization of the biofilm structure. After the addition of silver ions and within
60 min of contact, the overall structure of the biofilm became partially destroyed and the inner structure of biofilm was exposed.
There were also significant amounts of silver around the damaged biofilm colony, confirming the effect of silver ions on grown biofilm.”

Silver on Retinal Eye Therapies

Silver on Retinal Eye Therapies

Kalishwaralal et. al. 2010

“The study consequently affirm the application of silver nanoparticles as a boon to ocular therapies.”

Silver on Wound Healing

Silver on Wound Healing

Tian et. al. 2007

“The study investigated the wound-healing properties of silver nanoparticles in an animal model and found
that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through
quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert
positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation
of fibrogenic cytokines. These results show the actions of silver and have provided a novel therapeutic
direction for wound treatment in clinical practice.”

Silver Antifungal on Dermatophytes

Silver Antifungal on Dermatophytes

Kim et. al. 2008

“Spherical silver nanoparticles (nano-Ag) were synthesised and their antifungal effects on fungal pathogens of the
skin were investigated. Silver ions showed potent activity against clinical isolates of Trichophyton mentagrophytes
and Candida. The activity of Silver ions was comparable to that of amphotericin B, but superior to that of fluconazole
The results show that silver ions exert activity on the mycelia. The study indicates that Silver ions have considerable
antifungal activity.”

Silver as Candida Antifungal Activity

Silver as Candida Antifungal Activity

Monteiro et. al. 2011

“The Study show that 3 PPM silver is very acgtive against biofilm of fungai.”

Silver as Novel Anti-Parasite Activity

Silver as Novel Anti-Parasite Activity

Singh et. al. 2012

“The present report provides the first ever conclusive proof in support of apoptosis as a novel stratagem in
antifilarial drug designing and nanoscale silver as a valid lead in research on antifilarial therapeutics.
Effective microfilaricidal activity of nanosilver at relatively low concentrations as reported in this study,
with evidence of the induction of apoptosis in microfilariae, projects nanosilver as a potential drug adjuvant
against lymphatic filariasis. The much higher 50% lethal dose value of nanosilver compared to the complete
inhibitory concentration value reported in this study argues in favour of a safe therapeutic window of this
agent in its antifilarial efficacy.”

Silver on Asthma Prevention/Treatment

Silver on Asthma Prevention/Treatment

Park et. al. 2010

“An antioxidant effect of silver nanoparticles could be one of the molecular bases in the murine model of asthma.
These findings may provide a potential molecular mechanism of silver nanoparticles in preventing or treating asthma.”